منابع مشابه
The Possible Involvement of Nitric Oxide/Endothelium Derived Relaxing Factor in Atropine-Induced Vasorelaxation
Atropine has been used to block cholinergic neurotransmission in basic research. Large doses of atropine cause vasodilation of the blood vessels in the skin. This effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. It has been suggested that atropine blocks muscarinic receptors at low doses and it induces th...
متن کاملNitric oxide and coronary vascular endothelium adaptations in hypertension
This review highlights a number of nitric oxide (NO)-related mechanisms that contribute to coronary vascular function and that are likely affected by hypertension and thus become important clinically as potential considerations in prevention, diagnosis, and treatment of coronary complications of hypertension. Coronary vascular resistance is elevated in hypertension in part due to impaired endot...
متن کاملPlasma sodium stiffens vascular endothelium and reduces nitric oxide release.
Dietary salt plays a major role in the regulation of blood pressure, and the mineralocorticoid hormone aldosterone controls salt homeostasis and extracellular volume. Recent observations suggest that a small increase in plasma sodium concentration may contribute to the pressor response of dietary salt. Because endothelial cells are (i) sensitive to aldosterone, (ii) in physical contact with pla...
متن کاملRole of Scavenger Receptor and Endothelium-Derived Nitric Oxide
Background. We studied the effects of low density lipoprotein (LDL) on endothelium function. Methods and Results. Porcine epicardial and intramyocardial coronary arteries suspended in organ chambers for isometric tension recording were exposed to LDL for 2 hours and were then washed. In epicardial coronary arteries, oxidized LDL (30-300 ,ug/mI) but not native LDL or lysolecithin inhibited endot...
متن کاملPotassium softens vascular endothelium and increases nitric oxide release.
In the presence of aldosterone, plasma sodium in the high physiological range stiffens endothelial cells and reduces the release of nitric oxide. We now demonstrate effects of extracellular potassium on stiffness of individual cultured bovine aortic endothelial cells by using the tip of an atomic force microscope as a mechanical nanosensor. An acute increase of potassium in the physiological ra...
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ژورنال
عنوان ژورنال: Medicina
سال: 2008
ISSN: 1648-9144
DOI: 10.3390/medicina44070073